ABSTRACT
Background: Pharmacology is one of the most progressive and constantly changing basic medical science subject. The current curriculum of pharmacology lacks uniformity. Lectures, tutorials and practical classes are the common methods of teaching. The scientific and integrated curriculum and innovative teaching methodology fulfils the academic objectives
Objective: To know the students satisfaction and effectiveness of current teaching methods and curriculum in pharmacology. Methodology: This cross-sectional survey was conducted in Pharmacology Department, Sheikh Zayed Medical College, Rahim Yar Khan, from1stNovember to30th November 2017. A set of questionnaire was distributed among the 140, MBBS students of 3rd yearwho have studied pharmacology. Students were instructed to tick the best possible option of each question on the basis of their own perceptions. Analysis of data was done using SPSS version in 20. Descriptive analysis was used to assess different variables in the study
Results:140 students of 3rd year MBBS class participated in this study. Male students were 59 and 81 were female students with mean age of 21.5+/-1 with minimum age of 19 and maximum age of 24 years old. All students answered the questions and gave their opinion. Regarding the current teaching methodologies, 66.4% students were satisfied with current teaching methodology in comparison with 23.5 % who were not satisfied and 10% has no idea
Conclusion: In present study, overall students were satisfied with current teaching curriculum and they were of the view that integrated teaching should be added to the curriculum and teaching should include problem based learning, small group discussion, self-directed learning and bed side teaching in pharmacology
ABSTRACT
Background: Camel milk has been widely used as a dietry constituent in desert areas where camels are common. It has also been in use to cure a number of commonly occurring diseases
Objective: To investigate the hepato protective effect of camel milk in antituberculous drugs induced hepatotoxicity in rats
Methodology: This randomized control study was conducted on healthy male albino rats. 24 male albino rats [200-250gms] were obtained from National Institute of Health, Islamabad and kept in animal house of Pharmacology Department, Sheikh Zayed Medical College, Rahim Yar Khan. Rats were divided into 4-groups. Each group consisted of 6 rats. Rats were given nutritionally standard diet and recommended dosage of antituberculous drugs along with recommended quantity of camel milk. Data was entered and assessed by using SPSS version 17
Results: Hepatoprotective effect of camel milk was analyzed by liver function parameters as serum aminotransferases, alkaline phosphatases and lactate dehydrogenases. Data showed that antituberculous drugs given for 30 days developed severe liver damage. In biochemical study, there was significant raise in serum diagnostic liver marker enzyme [ALT, AST, ALP and LDH] levels in ATT treated rats. Coadministration of camel milk and antituberculous drugs led to significantly decreased enzyme levels. [P=0.01]
Conclusion: This study concluded that co-administration of camel milk can reduce the toxicity and damage of liver caused by antituberculous drugs
ABSTRACT
Study was designed to investigate the biochemical derangements induced by antituberculous drugs and role of onion extract in male albino rats. March to December 2008. Study was conducted on non-tuberculous male albino rats, which were kept in animal house of University of Health Sciences, Lahore. 48 male albino rats, obtained from NIH Islamabad weighing 200-250 gms were divided into four groups, each group consisting of 12 rats. Group A; received normal diet and fresh water orally. Group B; received normal diet, fresh water and antituberculous drugs orally. Group C; received 100mg/kg body weight of onion extract and antituberculous drugs orally and Group D; received 200mg/kg body weight of onion extracts and antituberculous drugs orally, rats were treated with this regimen for 45 days. After the last administration, blood samples were collected. Serum samples were separated into sterile appendorf tubes and stored at -20 C until used for estimation. Following methods were followed for biochemical investigations. Estimation of Serum Alanineaminotransferase [ALT] and estimation of serum Alkaline Phosphatase [ALP]. In this biochemical study; there was a significant elevation in the levels of serum diagnostic marker enzymes [ALT, ALP] in group B antituberculosis drugs administered rats as compared to that of non-antituberculosis drugs administered in group A. Co-administration of onion extract and antituberculous drugs, decreased enzyme levels were noticed in a dose dependent manner in group C and group D rat's serum samples. Antituberculous drugs causes significant elevations in the level of serum diagnostic marker enzymes [ALT and ALP] and onion extract lowers the enzyme levels indicating its cytoprotective effect